Intratumor Heterogeneity of the Estrogen Receptor and the Long-term Risk of Fatal Breast Cancer.

Author
:
LS Lindström
C Yau
K Czene
CK Thompson
KA Hoadley
LJ Veer
R Balassanian
JW Bishop
PM Carpenter
YY Chen
B Datnow
F Hasteh
G Krings
F Lin
Y Zhang
B Nordenskjöld
O Stål
CC Benz
T Fornander
AD Borowsky
LJ Esserman
Group. Trialists
Abstract
:

Breast cancer patients with estrogen receptor (ER)-positive disease have a continuous long-term risk for fatal breast cancer, but the biological factors influencing this risk are unknown. We aimed to determine whether high intratumor heterogeneity of ER predicts an increased long-term risk (25 years) of fatal breast cancer.
Year of Publication
:
2018
Journal
:
Journal of the National Cancer Institute
Date Published
:
2018
ISSN Number
:
0027-8874
URL
:
https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djx270
DOI
:
10.1093/jnci/djx270
Short Title
:
J Natl Cancer Inst
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