Identification of danthron as an isoform-specific inhibitor of HEME OXYGENASE-1/cytochrome P450 reductase interaction with anti-tumor activity.
| Author | |
|---|---|
| Abstract |
:
Heme oxygenase (HO) catalyzes NADPH-dependent degradation of heme to liberate iron, carbon monoxide and biliverdin. The interaction between HO and cytochrome P450 reductase (CPR), an electron donor, is essential for HO activity. HO-1 is a stress-inducible isoform whereas HO-2 is constitutively expressed. HO-1 induction is commonly seen in cancers and impacts disease progression, supporting the possibility of targeting HO-1 for cancer therapy. |
| Year of Publication |
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2018
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| Journal |
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Journal of biomedical science
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| Volume |
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25
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| Issue |
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1
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| Number of Pages |
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6
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| Date Published |
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2018
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| ISSN Number |
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1021-7770
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| URL |
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https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-018-0411-y
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| DOI |
:
10.1186/s12929-018-0411-y
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| Short Title |
:
J Biomed Sci
|
| Download citation |
