Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus.
| Author | |
|---|---|
| Abstract |
:
The antirelapse drug acamprosate has previously been reported to inhibit activating effects of polyamines on -methyl-D-aspartic acid receptor (NMDAR) function. Because increased synthesis of polyamines has been suggested as a mechanism for potentiation of NMDAR function during ethanol withdrawal, we evaluated the effects of acamprosate, MK-801, and ifenprodil in a cell culture model of ethanol withdrawal-induced neurotoxicity. |
| Year of Publication |
:
2002
|
| Journal |
:
Alcoholism, clinical and experimental research
|
| Volume |
:
26
|
| Issue |
:
10
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| Number of Pages |
:
1468-78
|
| ISSN Number |
:
0145-6008
|
| DOI |
:
10.1097/01.ALC.0000033261.14548.D2
|
| Short Title |
:
Alcohol Clin Exp Res
|
| Download citation |
