Ethanol Stimulates Endoplasmic Reticulum Inositol Triphosphate and Sigma Receptors to Promote Withdrawal-Associated Loss of Neuron-Specific Nuclear Protein/Fox-3.
| Author | |
|---|---|
| Abstract |
:
Prior studies demonstrate that ethanol (EtOH) exposure induces the release of intracellular calcium (CA(2+) ) in modulation of γ-aminobutyric acid-ergic tone and produces concomitant alterations in sigma (σ)-1 protein expression that may contribute to the development EtOH dependence. However, the influence of CA(2+) released from endoplasmic reticulum (ER)-bound inositol triphosphate (IP3) and σ-1 receptors in regulating hippocampal function has yet to be delineated. |
| Year of Publication |
:
2016
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| Journal |
:
Alcoholism, clinical and experimental research
|
| Volume |
:
40
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| Issue |
:
7
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| Number of Pages |
:
1454-61
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| ISSN Number |
:
0145-6008
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| URL |
:
https://doi.org/10.1111/acer.13097
|
| DOI |
:
10.1111/acer.13097
|
| Short Title |
:
Alcohol Clin Exp Res
|
| Download citation |
